When the 2004 tsunami hit the coast of Sri Lanka, 65-year-old Anton Ambrose's wife and daughter were killed. "In five minutes," he says, "I lost everything." A year later, Anton returns to Sri Lanka. With him is his nephew, award-winning filmmaker Rohan Fernando. A Tamil, Anton moved to California in the 1970s and became a very successful gynecologist. His daughter, Orlantha, made the opposite journey, returning to Sri Lanka where she ran a non-profit group that gave underprivileged children free violin lessons. Blood and Water is the story of one man's search for meaning in the face of overwhelming loss, but it is also filled with improbable characters, unintentional comedy and situational ironies.